INRIA Paris-Rocquencourt Centre

BP 105 - 78153 Le Chesnay Cedex - FRANCE

REGATE Large Scale Project

GdR REPRO

Blaise Pascal, Pensées

Mutiscale dynamics in the hypothalamo-hypophyso-gonadal axis

- B. Aymard, F. Clément, M. Postel. Adaptive mesh refinement strategy for a non conservative transport problem. To appear in
*ESAIM: Mathematical Modelling and Numerical Analysis* - P.A. Fletcher, F. Clément, A. Vidal, J. Tabak, R. Bertram. Interpreting frequency responses to dose-conserved pulsatile input signals in simple cell signaling motifs.
*PloS One*, 2014, 9(4): e95613. - D. Monniaux, F. Clément, R. Dalbiès-Tran, A. Estienne, S. Fabre, C. Mansanet, P. Monget. The ovarian reserve of primordial follicles and the dynamic reserve of antral growing follicles: what is the link?
*Biology of Reproduction*, ehead of pub. - B. Aymard, F. Clément, F. Coquel, M. Postel. A Numerical Method for Transport Equations with Discontinuous Flux Functions: Application to Mathematical Modeling of Cell Dynamics.
*SIAM Journal on Scientific Computing*, 2013, 35(6): A2442-A2468. - F. Clément, D. Monniaux, P. Michel, T. Stiehl. Coupled somatic cell kinetics and germ cell growth: multiscale model-based insight on ovarian follicular development.
*Multiscale Modeling & Simulation*, 2013, 11(3): 719-746. - M. Krupa, A. Vidal, F. Clément. A network model of the periodic synchronization process in the dynamics of calcium concentration in GnRH neurons.
*The Journal of Mathematical Neuroscience*, 2013, 3: 4. - F. Clément, D. Monniaux. Multiscale modelling of ovarian follicle selection.
*Progress in Biophysics and Molecular Biology*, 2013, 113(3): 398-408. - F. Clément, J.-M. Coron, P. Shang. Optimal control of cell mass and maturity in a model of follicular ovulation.
*SIAM Journal on Control and Optimization*, 2013, 51(2): 824-847. - M. Krupa, A. Vidal, M. Derosches, F. Clément. Mixed-mode oscillations in a multiple time scale phantom bursting system.
*SIAM Journal on Applied Dynamical Systems*, 2012, 11(4): 1458-1498. - B. Aymard, F. Clément, F. Coquel, M. Postel. Numerical simulation of the selection process of the ovarian follicles.
*ESAIM Proceedings*, 2012, 38: 99-117. - A. Vidal, Q. Zhang, C. Médigue, S. Fabre, F. Clément. DynPeak : An algorithm for pulse detection and frequency analysis in hormonal time series.
*PloS One*, 2012, 7: e39001. - C. Rico, C. Médigue, S. Fabre, P. Jarrier, M. Bontoux, F. Clément, D. Monniaux. Regulation of Anti-Müllerian Hormone production in the cow: a multi-scale study at endocrine, ovarian, follicular and granulosa cell levels.
*Biology of Reproduction*, 2011, 84(3): 560-571 - A. Vidal, F. Clément. A dynamical model for the control of the GnRH neurosecretory system.
*Journal of Neuroendocrinology*, 2010, 22(12): 1251-1266. - F. Clément, A. Vidal. Foliation-based parameter tuning in a model of the GnRH pulse and surge generator.
*SIAM Journal on Applied Dynamical Systems*, 2009, 8(4): 1591-1631. - A. Vidal, C. Médigue, B. Malpaux, F. Clément. Endogenous circannual rhythm in LH secretion: insight from signal analysis coupled with mathematical modeling.
*Philosophical Transactions of the Royal Society A*, 2009, 367, 4759-4777. - F. Clément. Multiscale modelling of endocrine systems: new insight on the gonadotrope axis.
*ESAIM Proceedings*, 2009, 27: 209-226. - X. Druart, J Cognié, G. Baril, F. Clément, J.-L. Dacheux, J.-L. Gatti. In vivo imaging of in situ motility of fresh and liquid stored ram spermatozoa in the ewe genital tract.
*Reproduction*, 2009, 138(7): 45-53. - C. Rico, S. Fabre, C. Médigue, N. di Clemente, F. Clément, M. Bontoux, J.-L. Touzé, M. Dupont, E. Briant, B. Rémy, J.-F. Beckers, D. Monniaux Anti-Mullerian hormone is an endocrine marker of ovarian gonadotropin responsive follicles and can help to predict superovulatory responses in the cow.
*Biology of Reproduction*, 2009, 80(1): 50-59. - N. Echenim, F. Clément, M. Sorine. Multiscale modeling of follicular ovulation as a reachability problem.
*Multiscale Modeling & Simulation*, 2007, 6(3): 895-912. - F. Clément, J.-P. Françoise. Mathematical modeling of the GnRH-pulse and surge generator.
*SIAM Journal on Applied Dynamical Systems*, 2007, 6(2): 441-456. - N. Echenim, D. Monniaux, M. Sorine, F. Clément. Multi-scale modeling of the follicle selection process in the ovary.
*Mathematical Biosciences*, 2005, 198: 57-79. - F. Clément, D. Monniaux, J.C. Thalabard, D. Claude. Contribution of a mathematical modelling approach to the understanding of ovarian function.
*Comptes Rendus Biologies*, 2002, 325: 473-485. - F. Clément, D. Monniaux, J. Stark, K. Hardy, J.C. Thalabard,
S. Franks, D.Claude. A mathematical model of FSH-induced cAMP production in ovarian follicles.
*American Journal of Physiology (Endocrinology & Metabolism)*, 281: E35-E53, 2001. - C. Pisselet, F. Clément, D. Monniaux. Fraction of proliferating
cells in granulosa during terminal follicular development in high and low
prolific sheep breeds.
*Reproduction, Nutrition, Development*, 40(3): 295-304, 2000. - F. Clément. Optimal control of the cell dynamics in the granulosa of ovulatory follicles.
*Mathematical Biosciences*, 152: 123-142, 1998. - F. Clément, M.A. Gruet, P. Monget, M. Terqui, E. Jolivet,
D. Monniaux. Growth kinetics of the granulosa cell population in ovarian
follicles : an approach by mathematical modelling.
*Cell Proliferation*, 30: 255-270, 1997. - D. Monniaux, C. Huet, N. Besnard, F. Clément, M. Bosc, C. Pisselet,
P. Monget, J.C. Mariana. Follicular growth and ovarian dynamics in
mammals.
*Journal of Reproduction and Fertility*, Suppl. 51: 3-23, 1997.

**Mathematical modelling and control of the cardiac electro-mechanical activity**

I was responsible for the coordination of the cooperative research initiative ICEMA-2 and ICEMA : Images of the Cardiac Electro-Mechanical Activity.

**Modelling and control of regulatory networks**

I was involved in this field as a participant of the GDyn cooperative research action : Dynamical Analysis of genetic regulatory networks.

last update 03/25/2014